Probiotics Powder
Akkermansia Muciniphila
Akkermansia muciniphila is a commensal bacterium that colonizes the intestinal mucus layer and is recognized as a promising candidate for the "next generation of probiotics".It uses intestinal mucin as its nutrient source and exhibits unique potential in
Description
What is Akkermansia muciniphila?
Akkermansia muciniphila is a commensal bacterium that colonizes the human intestinal mucus layer, accounting for 1% to 5% of the total gut microbiota. It uses mucin secreted by the intestine as its sole carbon and nitrogen source, sustaining itself by degrading mucin while stimulating intestinal epithelial cells to secrete more mucin, forming a “virtuous cycle”.This unique mechanism enables it to play a key role in maintaining intestinal barrier integrity, regulating metabolic inflammation, and improving insulin sensitivity.
As a representative of the “next-generation probiotics”, numerous studies have confirmed that Akkermansia muciniphila is inversely associated with obesity, type 2 diabetes, metabolic syndrome and inflammatory bowel disease.Currently, pasteurized Akkermansia muciniphila — favored for its greater stability and superior safety compared with the active form — is widely used as a functional ingredient in high-end probiotic supplements, metabolic health formulations and weight management products.
Product name: Akkermansia muciniphila probiotics powder
We supply more than 30 probiotics powder, and probioitcs blends, oil-soluble powder,
| PRODUCT NAME | Postbiotics powder | PROBIOTICS TYPE | Akkermansia muciniphila AH39 |
| PRODUCT FORM | Freeze dried powder | PACKAGE SIZE | 1/5kg |
| INNER PACKING | Aluminum Foil & PE Bag | OUTER PACKING | Foam Box & Carton |
| TEST ITEMS | SPECIFICATIONS | TEST METHODS | |
| Cell count (cells (TFU)/g) | ≥1.0×1011 (100B) | ISO 19344 IDF232 |
Physical & Chemical Properties
| Aspect | Powder | GB/T 29602 |
| Odor | No abnormal odor | GB/T 29602 |
| Moisture % | ≤5.0 | GB 5009.3 |
| Water activity | ≤0.2 | GB 5009.238 |
Heavy Metals
| *Lead (Pb) ppm | ≤0.05 | GB 5009.12 |
| *Arsenic (As) ppm | ≤0.5 | GB 5009.11 |
| *Cadmium (Cd) ppm | ≤0.05 | GB 5009.15 |
| *Mercury (Hg) ppm | ≤0.02 | GB 5009.17 |
Microbiology
| Aerobic mesophilic total count (CFU/g) | ≤500 | ISO 4833-1 | |
| Sulfite-reducing anaerobes (CFU/g) | ≤50 | ISO 15213 | |
| Coagulase + Staphylococci (CFU/g) | ≤10 | ISO 6888-2 | |
| Enterobacteriaceae (CFU/g) | ≤10 | ISO 21528-2 | |
| Bacillus cereus (CFU/g) | ≤100 | ISO 7932 | |
| Yeast & Mold (CFU/g) | ≤10 | GB 4789.15 | |
| *Listeria spp. | Negative in 25g | ISO 11290-1 | |
| *Salmonella spp. | Negative in 25g | ISO 6579-1 | |
| *Escherichia coli | Negative in 1g | ISO 16649-1 |
| * Represents type inspection. Shelf Life & Storage: At least 24 months if stored in a well-closed container away f  rom moisture anddirect sun light at room temperature. |
Intestinal Barrier Protection
Akkermansia colonizes the intestinal mucus layer and uses mucin as its nutrient source, while stimulating intestinal epithelial cells to secrete more mucus, forming a virtuous cycle.
This unique mechanism effectively thickens the mucus layer, strengthens intestinal barrier integrity, reduces the entry of harmful substances (such as endotoxins) into the bloodstream, and lowers systemic inflammation at the source.
Metabolic Improvement Function
Numerous studies have shown that the abundance of Akkermansia is significantly negatively correlated with obesity, type 2 diabetes, and insulin resistance. Supplementation with Akkermansia can:
- Improve insulin sensitivity and assist in blood glucose control
- Regulate lipid metabolism and reduce fat accumulation
- Reduce body weight and waist circumference, supporting healthy weight management
Anti-Inflammatory and Immune Modulation Function
By regulating the activity of intestinal immune cells (such as regulatory T cells), Akkermansia can reduce pro-inflammatory factor levels, exert anti-inflammatory effects in obesity-related inflammation, inflammatory bowel disease, and autoimmune diseases, and help restore immune homeostasis.
Cardiovascular Protection Function
Akkermansia offers potential cardiovascular protection by regulating bile acid metabolism, reducing oxidative stress, and improving the blood lipid profile (lowering triglycerides and total cholesterol).
Postbiotic Function (Pasteurized Form)
Commercial Akkermansia is mostly used in its pasteurized form. After inactivation, it fully retains its core functions of regulating the intestinal barrier and metabolism (such as the activity of the specific membrane protein Amuc_1100), with better stability and higher safety, making it easy to store and transport.It is an ideal ingredient for high-end probiotic supplements and functional foods.
Efficacy：Improve the intestinal barrier
•The accessibility of the Amuc-1100 protein was significantly enhanced by pasteurizing Akkermansia muciniphila.
• The expression of tight junction proteins in intestinal cells is influenced by AKK strains to improve the intestinal barrier.
• This heat-resistant protein works in synergy with the strain to help replenish the mucus layer in the intestinal barrier, thereby supporting the digestive, immune, and metabolic systems
Unique Intestinal Colonization Site
Akkermansia muciniphila is one of the few known commensal bacteria that colonize the intestinal mucus layer, using mucin secreted by the intestine as its sole carbon and nitrogen source.This unique ecological niche allows it to act as a "gatekeeper" in the gut microbiota, directly participating in maintaining intestinal barrier function.
Bidirectional Regulation Mechanism of the Mucus Layer
Akkermansia sustains itself by degrading mucus while stimulating intestinal epithelial cells to secrete more mucus, forming a "virtuous cycle".This bidirectional regulation not only ensures its own colonization but also strengthens the physical defense of the intestinal barrier.
Function Retained After Pasteurization
Commercially applied Akkermansia muciniphila is typically available in pasteurized (postbiotic) form.After heat treatment, its key functional components (such as the membrane protein Amuc_1100) remain fully intact, enabling it to continue regulating the intestinal barrier and improving metabolic inflammation.The inactivated form offers superior stability, higher safety, and easier storage and transportation, making it the industry standard.
Well-Established Metabolic Improvement Effects
Numerous preclinical and human studies have confirmed that the abundance of Akkermansia muciniphila is significantly negatively correlated with obesity, type 2 diabetes, and insulin resistance.Its mechanisms of action involve multiple pathways including enhancing intestinal barrier function, reducing endotoxemia, and regulating bile acid metabolism, providing solid scientific evidence for its metabolic benefits.
Excellent Safety Profile
Akkermansia muciniphila is a commensal bacterium naturally present in the human gut, and its pasteurized form has been confirmed safe through toxicological evaluation.It has been approved as a novel food ingredient in the European Union and recognized as GRAS (Generally Recognized As Safe) by the U.S. FDA, suitable for use in dietary supplements and functional foods.
Excellent Processability
Pasteurized Akkermansia muciniphila is supplied as a powder with high stability under dry conditions, facilitating storage and transportation.It is suitable for various dosage forms including capsules, tablets, powders, solid beverages, and functional foods, and shows good compatibility with dietary fiber, prebiotics, and other probiotics.
High Activity Retention
High-quality raw material suppliers adopt strict manufacturing processes to ensure the retention of active ingredients after pasteurization.Content analysis reports and stability data are provided to support efficacy claims for end products.
Metabolic Health Dietary Supplements
This is the core application scenario of Akkermansia muciniphila. Its key goal is to improve insulin sensitivity, blood glucose control and lipid metabolism by regulating gut microbiota balance, providing targeted microecological intervention for people with metabolic syndrome, type 2 diabetes and obesity.Blood glucose management formulas: such as blood glucose balance capsules and metabolic support powders.Akkermansia muciniphila improves insulin resistance and assists blood glucose control by strengthening intestinal barrier function and reducing endotoxemia
Weight management products: such as weight management supplements and metabolism-boosting formulas.Studies have shown that the abundance of Akkermansia muciniphila is negatively correlated with body weight; supplementation helps regulate energy metabolism and reduce fat accumulation.
Blood lipid regulation formulas: such as cardiovascular health supplements.It supports healthy blood lipid levels by regulating bile acid metabolism and inflammatory responses.
Weight management products: such as weight management supplements and metabolism-boosting formulas.Studies have shown that the abundance of Akkermansia muciniphila is negatively correlated with body weight; supplementation helps regulate energy metabolism and reduce fat accumulation.
Blood lipid regulation formulas: such as cardiovascular health supplements.It supports healthy blood lipid levels by regulating bile acid metabolism and inflammatory responses.
Intestinal Health & Immune Regulation
These products focus on intestinal barrier function and immune balance. Their core purpose is to repair the intestinal mucus layer, enhance intestinal barrier integrity, and improve inflammatory bowel disease, leaky gut syndrome and immune dysfunction.Intestinal repair formulas: such as leaky gut repair powders and intestinal health capsules.Akkermansia muciniphila utilizes intestinal mucus as a nutrient source, stimulates mucus layer renewal, strengthens the gut barrier, and reduces the entry of harmful substances into the bloodstream.
Immune regulation products: such as immune support capsules and anti-inflammatory formulas.It restores immune homeostasis by regulating the activity of intestinal immune cells and balancing pro and anti inflammatory responses.
High-End Probiotic Supplements
As a representative of the “next-generation probiotics”, Akkermansia muciniphila is gradually entering the high-end probiotic market, mostly used in pasteurized form (for better stability and safety) in combination with other probiotic strains.Combined probiotic formulas: blended with traditional probiotics such as Lactobacillus and Bifidobacterium to provide comprehensive gut microbiota support.
Postbiotic products: pasteurized Akkermansia muciniphila and its metabolites act as postbiotic ingredients to directly regulate the gut barrier and improve metabolism.
